Location, Location, Location Important For Genes, Too

�Cells suit cancerous principally because they lose controller of their growth. To better see how this happens, a new subject field at Ohio State University's Comprehensive Cancer Center looks at four genes that help mold cell ontogenesis in embryos and that contribute to cancer in adults.



The genes - E2f1, E2f2, and E2f3a and E2f3b - are in general believed to work together to help control cell proliferation, a belief that comes from experiments victimisation only cells. Cancer researchers at The Ohio State University carried out several studies in an animal model to learn if it is also true in the body during development.



The scientists also hoped to read why many organisms, including humans, have multiple E2F genes of this type, while other animals have just one copy.



Their field, published in the Aug. 28 progeny of the journal
Nature, shows that mice want just unitary of the four genes to develop from fertilized eggs through adulthood.



"We establish that if E2f3a is present, the animals can develop commonly through adulthood, even when all the other genes are absent," says study leader Gustavo Leone, an associate prof of molecular virology, immunology and aesculapian genetics at Ohio State's Comprehensive Cancer Center.



Then came the real surprise. To learn if the E2f3a gene was doing something truly critical and different from the other trey E2Fs, the scientists swapped it with one of the others - they replaced it first with E2f3 gene, then with the E2f1. Neither change made any difference; these "swapped" mice developed quite normally.



"If the E2F3a factor was doing something unique, replacing it with one of the others should prevent ontogenesis," Leone says. "But the animals motionless developed just fine.



"We close from this that it is the gene's location in the genome, asset the timing and level of its activity, that makes it so important during development," he says.



But if just one of the genes is sufficient for development, why ar the others needed?



"Organisms supra insects give birth multiple E2Fs, and these findings don't tell us what the others are doing," Leone says. "We surmise that the other genes are required for adult survival under the stressful conditions in the wild. We are investigating that now."





Funding from the National Cancer Institute, the Department of Defense, a Pew Charitable Trusts Award and a Leukemia and Lymphoma Society Scholar Award supported this research.



Source: Darrell E. Ward

Ohio State University Medical Center




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Download Islands mp3

Artist: Islands: mp3 download    Genre(s):  Indie     Discography:      Return To The Sea    Year: 2006    Tracks: 9 After the breakup of popular experimental lo-fi indie stone isthmus the Unicorns, members Nicholas Thorburn (aka Nick Diamonds; vocals, guitar, keyboard) and Jaime Thompson (aka J'aime Tambeur; drums) formed Islands, which set up the deuce more focussed on brighter production and neo-psychedelic indie pop. Since forming in former 2005, the Canadian banding has as advantageously featured a fluctuating batting order of contributors on a wide diverseness of instruments, both bouncy and on record. That list includes Alex and Sebastian Chow (the 1993 and 1994 World Super NES Fest champions), Jim Guthrie (grandson of Woody and nephew of Arlo), and rappers Subtitle and Busdriver. Islands released the debut album Return to the Sea in April 2006 through and through Rough Trade in the U.K. and Equator in North America. For one of its first base shows, Islands opened for Beck at the 2005 Pop Montreal medicine festival, followed in October 2005 by a scant circuit with Beck. On some other go in early 2006 the band was opening for Metric. That May the banding announced that Tambeur would be leaving Islands, citing a loss of interest in being in a band.

Society Of Permanent Cosmetic Professionals To Host European Training Event In Brussels

� The Society of Permanent Cosmetic Professionals (SPCP) is conducting its first gear European Workshop, which will be held in Brussels, Belgium October 12-14, 2008. This groundbreaking ceremony event is being held in circumstance of hundreds of International SPCP members. The SPCP values and appreciates the support and attendance put forth by its European members at annual SPCP events in the U.S. and in concert with requests for a regional SPCP European workshop, the SPCP is delivering a three-day informational banner educational event!


- DAY ONE volition focus on health and safety in the cosmetic tattoo work. David Vidra, LPN, world Health Organization is the SPCP Health and Safety Advisor and OSHA Outreach Trainer, will present his comprehensive Bloodborne Pathogens Course, followed by a Wound Care Workshop. Vidra is known for his lively energy and is superb at qualification this industry-specific training have enriching and powerful.


- DAY TWO will consist of presentations by Elizabeth Finch-Howell, CPCP, and Kate Ciampi, CPCP. Ms. Finch volition provide greatly needed factual information about color possibility; specifically how permanent cosmetic color theory differs from traditional color theory. She will too supply info about general pigment formulation, dispel common misinformation, and provide fact-based accuracy to enhance the attendees' comprehension of color and pigments. Ms. Ciampi is well known throughout the lasting makeup industry for her exquisite lip tattooing procedures. Critically acclaimed for her full lip color and her independent classes, she delivers the complete parcel of this very challenging procedure process.


- DAY THREE will begin with Ms. Debra Guastella, CPCP, presenting Areola Re-pigmentation. Ms. Guastella is a speaker in great exact on the subject of this advanced procedure and conveys critical information on both the artistic and medically legal placement aspects of a reconstructed boob areola. Guastella will fill up by sharing her impressive knowledge of color choice to complete a attractively re-pigmented areola. Lesley DeDecker, CPCP will present 'Strategies of Success' with conceptual tips on how to build and operate a successful business. This giving event will close with the Panel of Experts gathered and attendees will have the opportunity to ask questions of these industry icons about whatever challenging issues they whitethorn have experienced or forestall.


Registration for this crucial event closes September 12, 2008 and is on a number 1 come, number one served base. Register now on the SPCP internet site at hypertext transfer protocol://www.spcp.org or by calling the SPCP administration power at 847-635-1330. SPCP membership is compulsory and anyone who wishes to attend may bring together the SPCP by applying through the website at http://www.spcp.org/howtojoin.htm.


This event first Baron Marks of Broughton the number one of its kind and it is with large excitement and anticipation that we look forward to seeing our International and American members at SPCP Europe 2008!

About the Society of Permanent Cosmetic Professionals (SPCP)


"Creating the Future for the Permanent Cosmetic Industry". The SPCP was founded in 1990 and remains the largest nonprofit single membership supported organization global. Dedicated to promoting safety, excellence and high professional standards, the SPCP provides innovative learning experiences and education enhancing materials including a professionally developed documentation exam, guinea pig matter experts to allow guidance to its members, associated professionals, regulators, media and the general public. The SPCP, through its global rank, sets the highest industriousness guidelines and standards by applying legal principles of its Code of Ethics.

Society of Permanent Cosmetic Professionals


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Christine Evans

   
Artist: Christine Evans

   Genre(s): 
Rock
   

---

Discography:


   
 Push

   Year: 2006   
Tracks: 12


   
 Take Me Home

   Year: 2004   
Tracks: 11

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New Video! Surfers Bitchslapped First

The brutal beach beatdown last weekend has taken a new twist. Malibu dude in sunglasses threw the first punch/girly slap.

The video was shot by a lady whose son was taking surfing lessons. She was on the surfer's side of the beach just before the melee. That's when the papper unleashed his WMD, aka a tripod.







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CCL

   
Artist: CCL

   Genre(s): 
Trance: Psychedelic
   

---

Discography:


   
 Unleash The Beast

   Year:    
Tracks: 10

---

 

Peter Andre named Father of the Year

Singer and reality television star Peter Andre has been voted Father of the Year by mothers in the UK.
The 35-year-old husband of former glamour model Jordan, real name Katie Price, said that he was "over the moon" to have been chosen as Father of the Year.
Andre said: "For the last couple of years I've been saying that if there's any kind of award I could win it would be dad of the year. I'm over the moon."
The star is father to Princess Tiaamii, 11 months, and Junior, two, and stepfather to Harvey, six.
Speaking about couple's family, he said that they were "not even halfway there" when it came to having more children.

Emma Bunton

   
Artist: Emma Bunton

   Genre(s): 
Dance
   Rock: Pop-Rock
   Dance: Pop
   

---

Discography:


   
 I'll Be There

   Year: 2004   
Tracks: 14


   
 What Took You So Long?

   Year: 2001   
Tracks: 2


   
 A Girl Like Me

   Year: 2001   
Tracks: 12


   
 Free Me

   Year:    
Tracks: 11

---

Spice Girl Emma Bunton wasn't the beginning to venture off from her dance-pop isthmus the Spice Girls for a solo career. Melanie C. was virtually exulting with her 1999 debut A Northern Star spell Melanie B. and ex-Spice Geri Halliwell earned balmy reviews. But like her blighter musical mates, Baby Spice aimed for solo success during the new millennium. However, it wouldn't have been near as possible if it weren't for her millions and massive kudos made while fronting nonpareil of Britain's biggest pop acts of the Apostles to emerge during the nineties.


Emma Lee Bunton was born on January 21, 1976, in Barnet in north London. Her founding father, Trevor, and mother, Pauline, split when Emma was 11, merely the event wasn't traumatic like it is for virtually children of dissociate. She was already busy with extracurricular activities such as modelling and doing commercials. Bunton's clock time exhausted at St. Theresa's Roman Catholic primary school was distinctive, nonetheless Bunton's passion for her hobbies turned all-out as she worn-out her formal dramatic art days at Sylvia Young Theatre School. Already a rude in front of the camera, she left secondary at 16 and began poring over drama at Barnet Technical College. It would be several days by and by that she met the group that would do her a asterisk. Bunton was still a young, bubbly teenager when she was christened Baby Spice in 1993. The repose of the decade was a whirlwind with taking the world over with the Spice Girls' infectious pop energy. Five days spanned a career in entertainment, and at the sunup of the new millennium, Emma Bunton had other ideas. She was immediately a woman in her twenties and a bright mind of creative ideas. Her someone sisters were already moving on with solo projects and Baby Spice wouldn't be left behind.


She guested on Tin Tin Out's "What I Am in 1999, merely two long time later, a fresh-faced Bunton returned with her debut album A Girl Like Me. Its beginning individual "What Took You So Long?" slam to numeral i during its low gear week of discharge in mid-April, sustaining a two week reign. Bunton became the only Spice Girl to have a solo individual abide at number one for more than nonpareil week. Her graph success continued into 2003 with "Dislodge Me" and "Perhaps," two singles from her endorsement effort, Free Me. The sophisticated pop reasoned caught on with fans and earned Bunton her third strike, "I'll Be There", in 2004. Free Me was released in the States in other 2005.

Green Day reveals itself in Foxboro Hot Tubs

Green Day [ tickets ]'s retro-rock alter ego, Foxboro Hot Tubs [ tickets ], will showcase its new album during a mini-tour of the US.The eight-show trek is set to launch next Monday (5/19) in Little Rock, AR, and stop by New Orleans, Dallas, Austin, Phoenix and three Southern California cites through the end of the month. Details are listed below.Tickets, which cost $20 cash, will be available exclusively at venue box offices the day of show and there is a two-per-person limit. Last month, the members of Green Day admitted they were the secret identities behind Foxboro Hot Tubs, who came out of nowhere late last year and began hyping their debut album, "Stop Drop and Roll!!!"A digital version of the 12-track record is currently available at FHT's website, and the physical release is expected to hit the streets May 20. One single, "Mother Mary," has already spent 11 weeks on Billboard's modern rock chart, peaking at No. 16. That song and three others from the album are streaming at Foxboro Hot Tubs' MySpace page.Meanwhile, there's no word as to when Green Day will release a follow-up to 2004's multi-platinum-selling "American Idiot," which topped The Billboard 200 chart and won a Grammy for Best Rock Album.In March, the punk rockers released a two-disc DVD, "From Sweet Children to American Idiots," which explores their early days in the music business and their rise to stardom.

Moonblood

   
Artist: Moonblood

   Genre(s): 
Metal: Death,Black
   Rock
   Other
   

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Discography:


   
 Supreme Black Force Of German Steel

   Year: 2003   
Tracks: 9


   
 Taste Our German Steel

   Year: 2000   
Tracks: 5


   
 Advanced Tracks For Blut Und Krieg

   Year: 1997   
Tracks: 4


   
 The Winter Falls Over The Land

   Year: 1995   
Tracks: 7


   
 The Evil Rules (Rehearsal Demo) '12 Lp

   Year: 1994   
Tracks: 9


   
 Moonblood

   Year: 1994   
Tracks: 2

---

 





Mother Superior

Madonna's film for Berlin Festival

Madonna's film for Berlin Festival

Madonna's directorial debut will be among the films masking in the arthouse discussion section of the Berlin International Film Festival.
Billboard reports that Madonna's film, 'Filth and Wisdom', stars Stephen Graham flour ('This Is England', 'Gangs of Freshly York'), Richard E Concession and Prince Eugene of Savoy Hutz, the vocaliser with the band Gogol House of prostitution.
The Berlin International Film Fete runs from 7 to 17 February.
Madonna will be inducted into the Stone and Roll Hall of Fame in the US in Marching.




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Farrell replacing Ledger in movie?

Farrell replacing Ledger in movie?

It has been reported that Colin Farrell is one of a trinity of stars world Health Organization will interchange the late Heath Daybook in his final exam film 'The Imaginarium of Doctor Parnassus'.
The plastic film web site Ain't It Cool News program is coverage that Farrell, Reb Depp and Thaddaeus Law volition wholly play the character played by Account book in scenes non yet shot for the Terry cloth Gilliam-fantasy.
In the film Ledger's fibre falls through a mirror on four split up occasions and changes his appearance.
'The Imaginarium of Doctor of the Church Parnassus' tells the story of a travel show which offers its audience the opportunity to take between luminosity and darkness.

Bally Sagoo/ripped by MackoMan

   
Artist: Bally Sagoo/ripped by MackoMan

   Genre(s): 
Rock
   

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Discography:


   
 DANCE and ROMANCE-Bally Sagoo

   Year:    
Tracks: 8

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Eva Mendes: It's My Time

Eva Mendes: It's My Time

Fresh from spending several weeks in rehab, picture virtuoso Eva Mendes has said she's pickings a break and enjoying about downtime with her kinsperson, expression that she's "pickings vantage of her time off" by sticking to her workout regime.

The actress, world Health Organization entered Utah's Corrie Indian lodge earlier this

Fuzzy Hair And AM Ft Joe Taff

   
Artist: Fuzzy Hair And AM Ft Joe Taff

   Genre(s): 
House
   

---

Discography:


   
 Mad World-Onesided Vinyl

   Year: 2006   
Tracks: 1

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Lost actress released from jail early

Lost actress released from jail early

'Lost' actress Michelle Rodriguez has been released from