�Cells suit cancerous principally because they lose controller of their growth. To better see how this happens, a new subject field at Ohio State University's Comprehensive Cancer Center looks at four genes that help mold cell ontogenesis in embryos and that contribute to cancer in adults.
The genes - E2f1, E2f2, and E2f3a and E2f3b - are in general believed to work together to help control cell proliferation, a belief that comes from experiments victimisation only cells. Cancer researchers at The Ohio State University carried out several studies in an animal model to learn if it is also true in the body during development.
The scientists also hoped to read why many organisms, including humans, have multiple E2F genes of this type, while other animals have just one copy.
Their field, published in the Aug. 28 progeny of the journal
Nature, shows that mice want just unitary of the four genes to develop from fertilized eggs through adulthood.
"We establish that if E2f3a is present, the animals can develop commonly through adulthood, even when all the other genes are absent," says study leader Gustavo Leone, an associate prof of molecular virology, immunology and aesculapian genetics at Ohio State's Comprehensive Cancer Center.
Then came the real surprise. To learn if the E2f3a gene was doing something truly critical and different from the other trey E2Fs, the scientists swapped it with one of the others - they replaced it first with E2f3 gene, then with the E2f1. Neither change made any difference; these "swapped" mice developed quite normally.
"If the E2F3a factor was doing something unique, replacing it with one of the others should prevent ontogenesis," Leone says. "But the animals motionless developed just fine.
"We close from this that it is the gene's location in the genome, asset the timing and level of its activity, that makes it so important during development," he says.
But if just one of the genes is sufficient for development, why ar the others needed?
"Organisms supra insects give birth multiple E2Fs, and these findings don't tell us what the others are doing," Leone says. "We surmise that the other genes are required for adult survival under the stressful conditions in the wild. We are investigating that now."
Funding from the National Cancer Institute, the Department of Defense, a Pew Charitable Trusts Award and a Leukemia and Lymphoma Society Scholar Award supported this research.
Source: Darrell E. Ward
Ohio State University Medical Center
More info
Friday 5 September 2008
Tuesday 26 August 2008
Download Islands mp3
 Artist: Islands: mp3 download Genre(s): Indie Discography:  Return To The Sea Year: 2006 Tracks: 9 After the breakup of popular experimental lo-fi indie stone isthmus the Unicorns, members Nicholas Thorburn (aka Nick Diamonds; vocals, guitar, keyboard) and Jaime Thompson (aka J'aime Tambeur; drums) formed Islands, which set up the deuce more focussed on brighter production and neo-psychedelic indie pop. Since forming in former 2005, the Canadian banding has as advantageously featured a fluctuating batting order of contributors on a wide diverseness of instruments, both bouncy and on record. That list includes Alex and Sebastian Chow (the 1993 and 1994 World Super NES Fest champions), Jim Guthrie (grandson of Woody and nephew of Arlo), and rappers Subtitle and Busdriver. Islands released the debut album Return to the Sea in April 2006 through and through Rough Trade in the U.K. and Equator in North America. For one of its first base shows, Islands opened for Beck at the 2005 Pop Montreal medicine festival, followed in October 2005 by a scant circuit with Beck. On some other go in early 2006 the band was opening for Metric. That May the banding announced that Tambeur would be leaving Islands, citing a loss of interest in being in a band. |
Saturday 16 August 2008
Society Of Permanent Cosmetic Professionals To Host European Training Event In Brussels
� The Society of Permanent Cosmetic Professionals (SPCP) is conducting its first gear European Workshop, which will be held in Brussels, Belgium October 12-14, 2008. This groundbreaking ceremony event is being held in circumstance of hundreds of International SPCP members. The SPCP values and appreciates the support and attendance put forth by its European members at annual SPCP events in the U.S. and in concert with requests for a regional SPCP European workshop, the SPCP is delivering a three-day informational banner educational event!
- DAY ONE volition focus on health and safety in the cosmetic tattoo work. David Vidra, LPN, world Health Organization is the SPCP Health and Safety Advisor and OSHA Outreach Trainer, will present his comprehensive Bloodborne Pathogens Course, followed by a Wound Care Workshop. Vidra is known for his lively energy and is superb at qualification this industry-specific training have enriching and powerful.
- DAY TWO will consist of presentations by Elizabeth Finch-Howell, CPCP, and Kate Ciampi, CPCP. Ms. Finch volition provide greatly needed factual information about color possibility; specifically how permanent cosmetic color theory differs from traditional color theory. She will too supply info about general pigment formulation, dispel common misinformation, and provide fact-based accuracy to enhance the attendees' comprehension of color and pigments. Ms. Ciampi is well known throughout the lasting makeup industry for her exquisite lip tattooing procedures. Critically acclaimed for her full lip color and her independent classes, she delivers the complete parcel of this very challenging procedure process.
- DAY THREE will begin with Ms. Debra Guastella, CPCP, presenting Areola Re-pigmentation. Ms. Guastella is a speaker in great exact on the subject of this advanced procedure and conveys critical information on both the artistic and medically legal placement aspects of a reconstructed boob areola. Guastella will fill up by sharing her impressive knowledge of color choice to complete a attractively re-pigmented areola. Lesley DeDecker, CPCP will present 'Strategies of Success' with conceptual tips on how to build and operate a successful business. This giving event will close with the Panel of Experts gathered and attendees will have the opportunity to ask questions of these industry icons about whatever challenging issues they whitethorn have experienced or forestall.
Registration for this crucial event closes September 12, 2008 and is on a number 1 come, number one served base. Register now on the SPCP internet site at hypertext transfer protocol://www.spcp.org or by calling the SPCP administration power at 847-635-1330. SPCP membership is compulsory and anyone who wishes to attend may bring together the SPCP by applying through the website at http://www.spcp.org/howtojoin.htm.
This event first Baron Marks of Broughton the number one of its kind and it is with large excitement and anticipation that we look forward to seeing our International and American members at SPCP Europe 2008!
About the Society of Permanent Cosmetic Professionals (SPCP)
"Creating the Future for the Permanent Cosmetic Industry". The SPCP was founded in 1990 and remains the largest nonprofit single membership supported organization global. Dedicated to promoting safety, excellence and high professional standards, the SPCP provides innovative learning experiences and education enhancing materials including a professionally developed documentation exam, guinea pig matter experts to allow guidance to its members, associated professionals, regulators, media and the general public. The SPCP, through its global rank, sets the highest industriousness guidelines and standards by applying legal principles of its Code of Ethics.
Society of Permanent Cosmetic Professionals
More info
- DAY ONE volition focus on health and safety in the cosmetic tattoo work. David Vidra, LPN, world Health Organization is the SPCP Health and Safety Advisor and OSHA Outreach Trainer, will present his comprehensive Bloodborne Pathogens Course, followed by a Wound Care Workshop. Vidra is known for his lively energy and is superb at qualification this industry-specific training have enriching and powerful.
- DAY TWO will consist of presentations by Elizabeth Finch-Howell, CPCP, and Kate Ciampi, CPCP. Ms. Finch volition provide greatly needed factual information about color possibility; specifically how permanent cosmetic color theory differs from traditional color theory. She will too supply info about general pigment formulation, dispel common misinformation, and provide fact-based accuracy to enhance the attendees' comprehension of color and pigments. Ms. Ciampi is well known throughout the lasting makeup industry for her exquisite lip tattooing procedures. Critically acclaimed for her full lip color and her independent classes, she delivers the complete parcel of this very challenging procedure process.
- DAY THREE will begin with Ms. Debra Guastella, CPCP, presenting Areola Re-pigmentation. Ms. Guastella is a speaker in great exact on the subject of this advanced procedure and conveys critical information on both the artistic and medically legal placement aspects of a reconstructed boob areola. Guastella will fill up by sharing her impressive knowledge of color choice to complete a attractively re-pigmented areola. Lesley DeDecker, CPCP will present 'Strategies of Success' with conceptual tips on how to build and operate a successful business. This giving event will close with the Panel of Experts gathered and attendees will have the opportunity to ask questions of these industry icons about whatever challenging issues they whitethorn have experienced or forestall.
Registration for this crucial event closes September 12, 2008 and is on a number 1 come, number one served base. Register now on the SPCP internet site at hypertext transfer protocol://www.spcp.org or by calling the SPCP administration power at 847-635-1330. SPCP membership is compulsory and anyone who wishes to attend may bring together the SPCP by applying through the website at http://www.spcp.org/howtojoin.htm.
This event first Baron Marks of Broughton the number one of its kind and it is with large excitement and anticipation that we look forward to seeing our International and American members at SPCP Europe 2008!
About the Society of Permanent Cosmetic Professionals (SPCP)
"Creating the Future for the Permanent Cosmetic Industry". The SPCP was founded in 1990 and remains the largest nonprofit single membership supported organization global. Dedicated to promoting safety, excellence and high professional standards, the SPCP provides innovative learning experiences and education enhancing materials including a professionally developed documentation exam, guinea pig matter experts to allow guidance to its members, associated professionals, regulators, media and the general public. The SPCP, through its global rank, sets the highest industriousness guidelines and standards by applying legal principles of its Code of Ethics.
Society of Permanent Cosmetic Professionals
More info
Thursday 7 August 2008
Christine Evans
Artist: Christine Evans
Genre(s):
Rock
Discography:
Push
Year: 2006
Tracks: 12
Take Me Home
Year: 2004
Tracks: 11
Monday 30 June 2008
New Video! Surfers Bitchslapped First
The brutal beach beatdown last weekend has taken a new twist. Malibu dude in sunglasses threw the first punch/girly slap.
The video was shot by a lady whose son was taking surfing lessons. She was on the surfer's side of the beach just before the melee. That's when the papper unleashed his WMD, aka a tripod.
See Also
The video was shot by a lady whose son was taking surfing lessons. She was on the surfer's side of the beach just before the melee. That's when the papper unleashed his WMD, aka a tripod.
See Also
Wednesday 25 June 2008
Monday 16 June 2008
Peter Andre named Father of the Year
Singer and reality television star Peter Andre has been voted Father of the Year by mothers in the UK.
The 35-year-old husband of former glamour model Jordan, real name Katie Price, said that he was "over the moon" to have been chosen as Father of the Year.
Andre said: "For the last couple of years I've been saying that if there's any kind of award I could win it would be dad of the year. I'm over the moon."
The star is father to Princess Tiaamii, 11 months, and Junior, two, and stepfather to Harvey, six.
Speaking about couple's family, he said that they were "not even halfway there" when it came to having more children.
The 35-year-old husband of former glamour model Jordan, real name Katie Price, said that he was "over the moon" to have been chosen as Father of the Year.
Andre said: "For the last couple of years I've been saying that if there's any kind of award I could win it would be dad of the year. I'm over the moon."
The star is father to Princess Tiaamii, 11 months, and Junior, two, and stepfather to Harvey, six.
Speaking about couple's family, he said that they were "not even halfway there" when it came to having more children.
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